Denise
Denise J. Cai, PhD
Associate Professor
Member, Friedman Brain Institute
Chief, Affective Neuroscience
Member, Center for Neurotechnology and Behavior
Member, Ronald M. Loeb Center for Alzheimer’s Disease
Member, Lipschultz Center for Cognitive Neuroscience
Office: Hess 10-116
Twitter: @denisejcai
Email: denisecai@gmail.com
Pub Med / Google Scholar / CV
Denise J. Cai received her bachelor’s degree in Psychology from the University of California in San Diego in 2004 where she completed an honors thesis under the direction of Ebbe Ebbesen. While initially planning to pursue a law degree, she was captivated by the field of learning and memory and instead pursued a doctoral degree in psychology and behavioral neuroscience. She earned her PhD in 2010 at UC San Diego with Drs. Sara Mednick, Stephan Anagnostaras, and Michael Gorman. Denise completed her postdoctoral training with Alcino Silva at UCLA in 2017 with the support of an NRSA from NIMH. She joined the Icahn School of Medicine at Mount Sinai as an Assistant Professor in 2017, was promoted to Associate Professor in 2022, and received tenure in 2023. She has been named an Allen Institute Next Generation Leader, an American College of Neuropsychopharmacology Member, and a Klingenstein-Simons Fellow. Denise has been awarded a McKnight Memory and Cognitive Disorders Award, a One Mind Rising Star Award, and an NIH Director’s New Innovator Award.
Positions and Education
University of California, Los Angeles (2010-2017)
Postdoctoral Fellow, Alcino Silva Laboratory
University of California, San Diego (2005-2010)
PhD, Psychology & Behavioral Neuroscience, Mednick, Anagnostaras, Gorman Laboratories
University of California, San Diego (2000-2004)
BS in Psychology
Select Honors and Awards
McKnight Memory and Cognitive Disorders Award (2019-2023)
NARSAD Young Investigator Award (2019-2021)
Brain and Behavior Research Foundation (BBRF) Young Investigator Award (2019-2021)
Klingenstein-Simons Fellowship Award (2018-2021)
Brain Research Foundation Award (2018-2020)
Friedman Brain Institute Scholar Award, ISMMS (2018)
Botanical Center Pilot Award (2018)
Allen Institute Next Generation Leader (2017-2020)
McKnight Brain Research Foundation Innovator Award in Cognitive Aging and Memory Loss (2023)
Friedman Brain Institute Scholar Award (2023)
Brain and Behavior Research Foundation (BBRF) Daniel X. Freedman Honorable Mention
Irma T. Hirschl/Monique Weill-Caulier Research Award (2021-2026)
Mount Sinai Distinguished Scholar Award (2019)
NIH Director’s New Innovator Award (2019-2024)
One Mind Rising Star Award (2019-2022)
Interests
Outside of the lab:
My family (the kids!); dancing; reading; creating recipes and cooking; and socializing with friends and colleagues
Scientific:
Memory processing; trauma; sleep; aging; hippocampus and amygdala; calcium imaging; chemogenetics; optogenetics; closed-loop systems; open-source tool development; advancing diversity, equity, and inclusion in scientific research
Invited Presentations
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Upcoming
Spring Hippocampal Research, Verona, Italy
Engrams and Ensembles in Learning and Memory, Dublin, Ireland
Computational and Systems Neuroscience (COSYNE), Montreal, Canada
Chan Zuckerberg Initiative Neuroscience Annual Meeting, Location TBD
Yale Molecular Psychiatry's Seminar Series, New Haven, CT
Winter Conference on Neural Plasticity, Fiji
NIH Neuroscience Seminar, Bethesda, MD
2024
Westchester Medical Center (Virtual)
RIKEN Center for Brain Science, Wako, Japan
Korea Brain Institute, Daegu, South Korea
Keynote, Optogenetics Gordon Research Conference, Tuscany, Italy
Science Day, Vanderbilt University, Nashville, TN
Cognitive Neuroscience Society Symposium, Toronto, Canada
North Atlantic Microscopy Society Conference, NYU Langone Medical Center, New York, NY
Northwestern University, Evanston, IL
University of Chicago, Chicago, IL
University of Utah, Salt Lake City, UT
Utah Women in Neuroscience (UWiN) Speaker Series, Salt Lake City, UT
University of Alabama at Birmingham, Birmingham, AL
2023
American College of Neuropsychopharmacology Annual Meeting, Tampa, FL
Society for Neuroscience, Washington, DC
Tufts University, Boston, MA
McLean Hospital, Belmont, MA
University of British Columbia, Vancouver, Canada
Imaging Structure & Function in the Nervous System, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Exploring the Amygdala in Pathology and Physiology, Gordon Research Conference, Barcelona, Spain
Spring Hippocampal Research Conference, Verona, Italy
Memory Dogmas Reexamined, New York University, New York, NY
Janelia Causes and Implications of Representational Drift Meeting, Howard Hughes Research Campus, Ashburn, VA
Computational and Systems Neuroscience (COSYNE) Workshop, Montreal, Canada
Sunposium, Max Planck Florida Institute for Neuroscience, West Palm Beach, FL
Psychology Department Colloquium, Columbia University, New York, NY
Winter Conference on the Neurobiology of Learning and Memory, Park City, UT
Bioengineering Seminar Series, University of Washington, Seattle, WA
Winter Conference on Neural Plasticity, Los Cabos, Mexico
Society for Neuroscience minisymposium, Washington, DC
2022
ISN School on Miniaturized Fluorescence Microscopy, Buenos Aires, Argentina
Student-Nominated Speaker: Department of Neuroscience, University of Texas, Austin
Imaging Structure & Function in the Nervous System, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
GRC Neurobiology of Cognition, Newry, ME
Sculpted Light in the Brain, Boston, MA
American Society for Cell Biology Committee for Postdocs and Students (ASCB-COMPASS) Webinar (Virtual)
McKnight Endowment Fund for Neuroscience, Aspen, CO
NeuroWire Virtual Club (Virtual)
Neurizons, Max Planck Research School for Neurosciences (Virtual)
Brain and Behavior Research Foundation (Virtual)
Trainee Health and Wellness Committee, Icahn School of Medicine at Mount Sinai (Virtual)
Department of Neuroscience, University of Texas, Austin (Virtual)
Computational and Systems Neuroscience (COSYNE) Workshop, Cascais, Portugal
Department of Neuroscience, Pennsylvania State University (Virtual)
2021
Department of Neuroscience, University of Texas, Austin
Rockefeller University, New York, NY
Department of Neuroscience, University of Minnesota, Minneapolis
The Broad Institute of MIT and Harvard, Boston, MA
NSF-sponsored Rocky Mountain Summit, University of Colorado, CO
Klingenstein-Simons Foundation Annual Meeting, New York, NY
Department of Engineering, Duke University, Raleigh-Durham, NC
Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, NY
Society for Neuroscience (SfN) Connectome Conference, Virtual Event
Cybertalk Seminar, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY
Max Planck Florida Institute for Neuroscience, Jupiter, FL
Neurophotonics Program, Boston University, Boston, MA
2020
Neurosciences Graduate Program Seminar Series, University of California-San Diego
Neurophotonics Program, Boston University, Boston, MA
Department of Psychology and Neuroscience, University of North Carolina, Chapel Hill, NC
Winter Brain Conference, Big Sky, MT
Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel
Swammerdam Lecture Series, University of Rotterdam, Amsterdam
IBRO World Congress of Neuroscience Meeting, Daegu, Korea
Molecular and Cellular Cognition Society (MCCS) Asia, Seoul, South Korea
2019
American College of Neuropsychopharmacology Meeting, Orlando, FL
Department of Neuroscience, Weill Cornell Medical College, New York, NY
Center for Developmental Neuroscience, College of Staten Island, CUNY, New York, NY
Behavioral and Cognitive Neuroscience, City University of New York-Manhattan (CUNY), New York, NY
Neuroscience Center Retreat, University of Alabama, Birmingham, AL
One Mind Rising Star Music Festival, Napa Valley, CA
European Behavioral Pharmacology Society, Braga, Portugal
Uniformed Services University, Bethesda, MD
Oxford Neuroscience, Oxford University, Oxford, UK
Hippocampal Research Conference, Taormina, Italy
Department of Neurobiology, University of Chicago, Chicago, IL
SPIE Neurophotonics West Conference, San Francisco, CA
2018
Allen Institute/Salk Institute Meeting, La Jolla, CA
Pavlovian Society Meeting, Iowa City, IA
Federation of European Neuroscience Societies, Berlin, Germany
NeuroFutures Conference, Seattle, WA
International Conference on Learning and Memory, University of California, Irvine, CA
Computational and Systems Neuroscience (Cosyne) Conference, Denver, CO
Winter Conference on Neurobiology of Learning and Memory, Park City, UT
2017
Allen Institute Showcase, Seattle, WA
NIEHS Neurobiology Seminar Series, Durham, NC
Center for the Memory and Brain Seminar Series, Boston University, Boston, MA
Center for Learning and Memory, University of Texas, Austin, TX
Hippocampal Research Conference, Taormina, Italy
Department of Neuroscience, The Johns Hopkins University of Medicine Mind/Brain Institute, Baltimore, MD
Department of Neuroscience, The Salk Institute, La Jolla, CA
Department of Neuroscience, The University of Pennsylvania, Philadelphia, PA
Department of Neuroscience, Yale University, New Haven, CT
Psychological and Brain Sciences, Dartmouth College, Dartmouth, NH
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Computational and Systems Neuroscience (COSYNE), Montreal, Canada (2023)
Calcium and Voltage Imaging Dynamics, Panelist, New York, NY (2023)
ISN School on Miniaturized Fluorescence Microscopy, Buenos Aires, Argentina (2022)
Co-Organizer, Optogenetics Gordon Research Conference, Newry, ME (2022)
2021 Virtual Miniscopes Workshop, Hosted by Metacell (2021)
Chan Zuckerberg Initiative Workshop, Virtual presentation (2021)
Miniscope Workshop, Israeli Society for Neuroscience, Tel Aviv, Israel (2020)
Department of Neuroscience, Jiao Tong University, Shanghai, China (2019)
Society for Neuroscience Annual Conference, Chicago, IL (2019, 2018)
Neuroscience Program, University of Utah, Salt Lake City (2018)
Cold Spring Harbor Laboratory Imaging Course (2018)
Society for Neuroscience, Washington, DC (2018)
Ludwig-Maximilians-Universitӓt München, Munich, Germany (2017)
Molecular Cellular Cognition Society, San Diego, CA (2017)
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“Asian American Women in Science and Medicine,” The Mount Sinai Health System, New York, NY (2021)
“Addressing the Leaky Pipeline in Science: Issues Facing New Moms,’ Society of Neuroscience (SfN) Annual Meeting (2018)
“Is it Really Harder to Be a Woman in Neuroscience?” Diverse Brains Seminar Series, the Icahn School of Medicine at Mount Sinai (2018)
Professional Leadership and Service
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Elected Secretary, Molecular and Cellular Cognition Society (2024 - present)
Co-Director, Computational and Systems Neuroscience Center, Icahn School of Medicine at Mount Sinai (2024 - present)
Co-Chair, Diversity, Equity, Inclusion, and Accessibility Committee, COSYNE Annual Meeting (2023-2025)
Member, Diversity, Equity, Inclusion, and Accessibility Committee, COSYNE 2024 Annual Meeting
Elected Member, American College of Neuropsychopharmacology (2022)
Appointed Co-Chair, Diversity, Equity, and Inclusion Committee, Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai (2020 - present)
Elected Member, Memory Disorders Research Society (2021)
Chair, Optogenetics Gordon Research Conference (2021-2022)
Vice-Chair, Optogenetics Gordon Research Conference (2019-2020)
Co-Chair, Hippocampus Meeting Symposium (2019-2022)
Co-Chair, American College of Neuropsychopharmacology Conference Panel (2019)
Member, Women’s Task Force, American College of Neuropsychopharmacology (2019)
Co-Chair, Allen Institute Next Generation Leader Council (2018-2019)
Elected Associate Member, American College of Neuropsychomarmacology (2017)
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Appointed Member, UC Irvine Center for the Neurobiology of Learning and Memory Fellow (2024 - present)
Functional Assays Working Group, Psychedelics Research Initiative, Coalition for Aligning Science (2024 - present)
Appointed Member, Faculty Advisory Committee, Mount Sinai Neuroscience Seminars (MSNseminars), Icahn School of Medicine at Mount Sinai (2022 - Present)
PhD Thesis Committees (Internal and External Reviewer): 15 (Icahn School of Medicine at Mount Sinai Labs: Kiraly, Goate, Nicolas-Harony, Russo, Schiller, Slesinger, Shaefer)
Appointed to Mentoring Team for the NIH FIRST (Faculty Institutional Recruitment for Sustainable Transformation) Cohort Initiative at the Icahn School of Medicine at Mount Sinai (2021)
Appointed Member, Committee on Anti-Asian Bias, ISMMS (2021 - present)
Appointed Co-Chair, Diversity, Equity, and Inclusion Committee, Nash Family Department of Neuroscience (2020 - present)
Appointed Member, Diverse Brains Committee (2020)
Appointed Co-Chair, Faculty Retreat, Friedman Brain Institute (2020)
Co-Mentor for K99/R00 Pathway to Independence Award – Dr. Sarah Stern; postdoctoral fellow, Friedman Lab, Rockefeller University; PI Stern Lab, Max Planck Institute, FL
Co-Mentor for K99/R00 Pathway to Independence Award – Dr. Kirstie Cummings; postdoctoral fellow, Clem Lab, Icahn School of Medicine at Mount Sinai; PI Cummings Lab, University of Alabama, Birmingham
Appointed Chief, Center for Affective Neuroscience, Nash Family Department of Neuroscience (2018)
Appointed Member, Department of Neuroscience Faculty Search Committee (2018)
Appointed Co-host, Annual Friedman Brain Institute Retreat (2018)
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Program Committee, Emerging Neurotechnology Course, Max Planck Florida Institute for Neuroscience
At ISMMS: Neurocore 3, Co-director
Invited Lecturer, Imaging Structure & Function in the Nervous System Course, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Adjunct Instructor, UCSD Department of Psychology, San Diego, CA
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eLife, Reviewer
Behavioral Neuroscience, Consulting editor
Biological Psychiatry, Reviewer
Cell, Reviewer
Cognitive Computation, Reviewer
Current Opinion in Neurobiology, Reviewer
Journal of Neuroscience, Reviewer
Molecular Psychiatry, Reviewer
Nature, Reviewer
Nature Communications, Reviewer
Nature Methods, Reviewer
Nature Neuroscience, Reviewer
Neuron, Reviewer
Neuropsychopharmacology, Reviewer
PLOS Computational Biology, Reviewer
Science, Reviewer
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Reviewer, NIH BRAIN Initiative: Targeted BRAIN Circuits, 2022
NIH, Ad Hoc Reviewer, Learning, Memory, and Decision Neuroscience (2019-2020)
Service for Broader Outreach and Engagement
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Volunteered at a booth open to local students and community members
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Panelist for a seminar course
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Panelist on two panels: Managing Money, Time, and Information and Leading Your Lab
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Presented a seminar about issues and successes for women in STEM during the UW Center of Neurobiology of Addiction, Pain, and Emotion Seminar Series
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The Cai Lab has hosted 3 high school interns, including Anthony Imbert (Posse STEM Scholar), as part of the Sherman Scholars Program at the Icahn School of Medicine at Mount Sinai
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Served as a mentor during a Society for Neuroscience-sponsored social for underrepresented people in STEM
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Hosted by the Trainee Health and Wellness Committee at the Icahn School of Medicine at Mount Sinai
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The Cai lab hosted students from the Harlem Educational Activities (HEAF) Program for a 6-week program of remote learning about foundational concepts in neuroscience and themes related to careers in neuroscience. Undergraduate interns, PhD students, and postdoctoral fellows served as near-peer and senior mentors.
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Invited presentation (via Zoom) to the Board of Trustees and Major Donors hosted by the Friedman Brain Institute and the Office for Development at the Icahn School of Medicine at Mount Sinai to discuss the importance of basic science and translational research in trauma.
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Invited presentation hosted by the Brain and Behavior Research Foundation in New York for guests from the Philanthropists Circle of China and from prominent science research funding agencies in the US.